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|Title:||Normal and premature rupture of fetal membranes at term delivery differ in regional chemotactic activity and related chemokine/cytokine production|
|Author:||Gomez-Lopez, Nardhy Yadira|
Lobb, Andrew Peter
Olson, David M.
|Citation:||Reproductive Sciences, 2013; 20(3):276-284|
|School/Discipline:||School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology|
|Nardhy Gomez-Lopez, Susana Hernandez-Santiago, Andrew P. Lobb, David M. Olson, and Felipe Vadillo-Ortega|
|Abstract:||A gradient of immunological mediators exists in the fetal membranes from the periplacental zone (PZ) to the rupture zone (RZ) at term delivery (rupture of fetal membranes [ROM]). However, it is unknown if this gradient is different in premature rupture of these tissues (premature rupture of fetal membranes [PROM]). We therefore analyzed leukocyte chemotactic activity and chemokine/cytokine production in fetal membrane zones in ROM and PROM. In ROM, leukocyte chemotactic activity increased from the PZ to the RZ; however, this did not occur in PROM. This was due to consistently elevated leukocyte chemotactic activity in PROM compared to ROM tissues. In the RZ, ROM was characterized by increased T-cell attraction and high levels of chemokine (C-X-C motif) ligand 8 (CXCL-8)/interleukin 8, and PROM by increased granulocyte attraction and high levels of granulocyte-macrophage colony-stimulating factor and CXCL-10/interferon gamma-induced protein 10. We conclude that normal and premature rupture of fetal membranes differ in regional chemotactic activity and related chemokine/cytokine production, which may represent evidence for differential mechanisms of rupture at term delivery.|
|Keywords:||chemotactic activity; fetal membranes; labor; leukocytes; PROM; ROM|
|Rights:||© The Author(s) 2012|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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