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Type: Journal article
Title: The role of ATP-binding cassette transporters in bacterial pathogenicity
Author: Pederick, V.
Ween, M.
McDevitt, C.
Citation: Protoplasma, 2012; 249(4):919-942
Publisher: Springer Wien
Issue Date: 2012
ISSN: 0033-183X
Statement of
Victoria G. Lewis & Miranda P. Ween & Christopher A. McDevitt
Abstract: The ATP-binding cassette transporter superfamily is present in all three domains of life. This ubiquitous class of integral membrane proteins have diverse biological functions, but their fundamental role involves the unidirectional translocation of compounds across cellular membranes in an ATP coupled process. The importance of this class of proteins in eukaryotic systems is well established as typified by their association with genetic diseases and roles in the multi-drug resistance of cancer. In stark contrast, the ABC transporters of prokaryotes have not been exhaustively investigated due to the sheer number of different roles and organisms in which they function. In this review, we examine the breadth of functions associated with microbial ABC transporters in the context of their contribution to bacterial pathogenicity and virulence.
Keywords: ABC transporter; Prokaryote; Pathogenicity; Virulence; Drug resistance; Secreted toxin
Rights: © Springer-Verlag 2012
RMID: 0020122368
DOI: 10.1007/s00709-011-0360-8
Appears in Collections:Molecular and Biomedical Science publications

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