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https://hdl.handle.net/2440/74720
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Type: | Journal article |
Title: | Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome |
Author: | Moran, L. Noakes, M. Wittert, G. Clifton, P. Norman, R. |
Citation: | Reproductive Biomedicine Online, 2012; 25(5):500-503 |
Publisher: | Reproductive Healthcare Ltd. |
Issue Date: | 2012 |
ISSN: | 1472-6483 1472-6491 |
Statement of Responsibility: | Lisa J Moran, Manny Noakes, Gary A Wittert, Peter M Clifton, Robert J Norman |
Abstract: | Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n=14) and without (n=13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P=0.026) and sICAM-1 (P=0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss. |
Keywords: | cardiovascular disease inflammation polycystic ovary syndrome weight loss |
Rights: | Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.rbmo.2012.07.013 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1016/j.rbmo.2012.07.013 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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