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Type: Journal article
Title: Low copy number of the Fc-γ receptor ₃B gene FCGR₃B is a risk factor for primary Sjögren's syndrome
Other Titles: Low copy number of the Fc-gamma receptor (3)B gene FCGR(3)B is a risk factor for primary Sjogren's syndrome
Author: Nossent, J.
Rischmueller, M.
Lester, S.
Citation: Journal of Rheumatology, 2012; 39(11):2142-2147
Publisher: J Rheumatol Publ Co
Issue Date: 2012
ISSN: 0315-162X
Statement of
Johannes C. Nossent, Maureen Rischmueller And Sue Lester
Abstract: OBJECTIVE. Immune complexes play an important role in the pathogenesis of primary Sjögren’s syndrome (pSS). Crosslinking of the neutrophil-specific Fc-γ receptor 3b (FCGR3B) facilitates immune complex clearance, and copy number variation (CNV) of the FCGR3B gene is known to reduce the uptake, and potentially clearance, of circulating immune complexes. Our objective was to determine whether FCGR3B CNV is a risk factor for pSS. METHODS. This was a cross-sectional study of patients with established pSS (n = 174) and population-matched controls (n = 162). FCGR3B CNV was determined by a quantitative real-time polymerase chain reaction assay, using genomic DNA as template and Taqman chemistry. Reactions were performed as a duplex, with RNAse P as the reference gene. Clinical and serological data were analyzed for their association with FCGR3B copy number (CN). RESULTS. Low FCGR3B CN (< 2 copies) was a risk factor for pSS in this cohort (p = 0.016), and combined results from this and a previous study yielded an overall OR of 2.3 (95% CI 1.3, 3.9, p = 0.003). Among patients with pSS in our cohort, low FCGR3B CN was not associated with anti-Ro ± La autoantibodies, but was associated with lower rheumatoid factor titers (p = 0.001) and serum IgG levels (p = 0.031). CONCLUSION. We confirmed that, similarly to other systemic autoimmune diseases, FCGR3B CN is a genetic susceptibility factor for pSS. As in rheumatoid arthritis, the mechanism does not appear to be related to seropositivity for characteristic autoantibodies.
Keywords: Fcgr3b; Gene Copy Number; Sjögrens’ Syndrome; Neutrophils
Rights: Copyright status unknown
RMID: 0020122831
DOI: 10.3899/jrheum.120294
Appears in Collections:Medicine publications

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