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Type: Journal article
Title: Altered pregnancy outcomes in mice following treatment with the hyperglycaemia mimetic, glucosamine, during the periconception period
Author: Schelbach, C.
Robker, R.
Bennett, B.
Gauld, A.
Thompson, J.
Kind, K.
Citation: Reproduction Fertility and Development, 2013; 25(2):405-416
Publisher: C S I R O Publishing
Issue Date: 2013
ISSN: 1031-3613
Statement of
Cheryl J. Schelbach, Rebecca L. Robker, Brenton D. Bennett, Ashley D. Gauld, Jeremy G. Thompson and Karen L. Kind
Abstract: Exposure of cumulus–oocyte complexes to the hyperglycaemia mimetic, glucosamine, during in vitro maturation impairs embryo development, potentially through upregulation of the hexosamine biosynthesis pathway. This study examined the effects of in vivo periconception glucosamine exposure on reproductive outcomes in young healthy mice, and further assessed the effects in overweight mice fed a high-fat diet. Eight-week-old mice received daily glucosamine injections (20 or 400 mg kg⁻¹) for 3–6 days before and 1 day after mating (periconception). Outcomes were assessed at Day 18 of gestation. Glucosamine treatment reduced litter size independent of dose. A high-fat diet (21% fat) for 11 weeks before and during pregnancy reduced fetal size. No additional effects of periconception glucosamine (20 mg kg⁻¹) on pregnancy outcomes were observed in fat-fed mice. In 16-week-old mice fed the control diet, glucosamine treatment reduced fetal weight and increased congenital abnormalities, but did not alter litter size. As differing effects of glucosamine were observed in 8-week-old and 16-week-old mice, maternal age effects were assessed. Periconception glucosamine at 8 weeks reduced litter size, whereas glucosamine at 16 weeks reduced fetal size. Thus, in vivo periconception glucosamine exposure perturbs reproductive outcomes in mice, with the nature of the outcomes dependent upon maternal age.
Keywords: fetal development; hexosamine biosynthesis pathway
Rights: © CSIRO 2012
RMID: 0020122782
DOI: 10.1071/RD11313
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Appears in Collections:Animal and Veterinary Sciences publications
IPAS publications

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