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https://hdl.handle.net/2440/74804
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dc.contributor.author | Counago, R. | - |
dc.contributor.author | McDevitt, C. | - |
dc.contributor.author | Ween, M. | - |
dc.contributor.author | Kobe, B. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Current Drug Targets, 2012; 13(11):1400-1410 | - |
dc.identifier.issn | 1389-4501 | - |
dc.identifier.issn | 1873-5592 | - |
dc.identifier.uri | http://hdl.handle.net/2440/74804 | - |
dc.description.abstract | The rapid emergence of multidrug-resistant bacteria over the last two decades has catalyzed a shift away from traditional antibiotic development strategies and encouraged the search for unconventional drug targets. Prokaryotic substrate- binding proteins (SBPs), together with their cognate ATP-binding cassette (ABC) transporters, facilitate the unidirectional, transbilayer movement of specific extracytosolic cargoes against a concentration gradient, powered by ATP hydrolysis. In Gram-negative bacteria, SBPs are found in the periplasmic space, whereas in Gram-positive organisms these proteins are anchored to the outer cell wall by a lipid moiety. SBPs are vital components of the substrate-translocation machinery, as they determine cargo specificity and are involved in coupling the cargo uptake process with ABC transporter- mediated ATP hydrolysis. In this review, we focus on "Cluster A-1" divalent metal-binding proteins from within the SBP family. Acquisition of transition row metal ions is essential for bacterial colonization and virulence and Cluster A-1 SBPs play an integral role in this process. Cluster A-1 SBPs lack homologs in humans, bypass the need to deliver compounds into the bacterial cell, and are therefore potential drug targets against Gram-positive bacteria. Here we discuss the role SBPs play in the prokaryotic substrate-translocation machinery with emphasis in the substrate-binding mechanism of Cluster A-1 SBPs, the role of these proteins in virulence and their potential use as drug targets. | - |
dc.description.statementofresponsibility | M. Counago, Rafael; A. McDevitt, Christopher; P. Ween, Miranda; Kobe, Bostjan | - |
dc.language.iso | en | - |
dc.publisher | Bentham Science Publishers Ltd. | - |
dc.rights | © 2012 Bentham Science Publishers | - |
dc.source.uri | http://dx.doi.org/10.2174/138945012803530170 | - |
dc.subject | ABC transporter | - |
dc.subject | ATP-binding cassette | - |
dc.subject | antimicrobials | - |
dc.subject | bacterial pathogens | - |
dc.subject | Cluster A-1 SBP | - |
dc.subject | drug design | - |
dc.subject | metal binding | - |
dc.subject | substrate-binding protein (SBP). | - |
dc.title | Prokaryotic substrate-binding proteins as targets for antimicrobial therapies | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2174/138945012803530170 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1022240 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/565526 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McDevitt, C. [0000-0003-1596-4841] | - |
dc.identifier.orcid | Ween, M. [0000-0002-0600-4585] | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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