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Type: Journal article
Title: Enzyme activity assays within microstructured optical fibers enabled by automated alignment
Author: Warren-Smith, S.
Nie, G.
Schartner, E.
Salamonsen, L.
Monro, T.
Citation: Biomedical Optics Express, 2012; 3(12):1-10
Publisher: Optical Society of America
Issue Date: 2012
ISSN: 2156-7085
Statement of
Stephen C. Warren-Smith, Guiying Nie, Erik P. Schartner, Lois A. Salamonsen, and Tanya M. Monro
Abstract: A fluorescence-based enzyme activity assay has been demonstrated within a small-core microstructured optical fiber (MOF) for the first time. To achieve this, a reflection-based automated alignment system has been developed, which uses feedback and piezoelectric actuators to maintain optical alignment. The auto-alignment system provides optical stability for the time required to perform an activity assay. The chosen assay is based on the enzyme proprotein convertase 5/6 (PC6) and has important applications in women's health.
Keywords: (060.2370) Fiber optics sensors
(060.4005) Microstructured fibers
(280.1415) Biological sensing and sensors
Rights: © 2012 OSA
DOI: 10.1364/BOE.3.003304
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