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https://hdl.handle.net/2440/74892
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Type: | Journal article |
Title: | Continuous glucose monitoring and cognitive performance in type 2 diabetes |
Author: | Pearce, K. Noakes, M. Wilson, C. Clifton, P. |
Citation: | Diabetes Technology and Therapeutics, 2012; 14(12):1-8 |
Publisher: | Mary Ann Liebert, Inc Publishers |
Issue Date: | 2012 |
ISSN: | 1520-9156 1557-8593 |
Statement of Responsibility: | Karma L. Pearce, Manny Noakes, Carlene Wilson, and Peter M. Clifton |
Abstract: | BACKGROUND: Type 2 diabetes is associated with reductions in cognitive function that are associated with glycated hemoglobin (HbA1c) levels, but there is no information on whether cognition is related to postmeal glucose spikes. We explored the relationship of cognition to glucose levels measured by a continuous glucose monitoring system (CGMS) both before and after a weight loss diet. SUBJECTS AND METHODS: Forty-four white subjects with type 2 diabetes (59.0±6.2 years old; body mass index, 32.8±4.2 kg/m2; HbA1c, 6.9±1.0%) completed an 8-week energy-restricted (approximately 6–7 MJ, 30% deficit) diet. Cognitive functioning (short-term memory, working memory, speed of processing [inspection time], psychomotor speed, and executive function) was assessed during four practice sessions, baseline, and Week 8. Parallel glucose levels were attained using the CGMS in 27 subjects. Outcomes were assessed by fasting blood glucose (FBG), postprandial peak glucose (Gmax), time spent >12 mmol/L (T>12), and 24-h area under the glucose curve (AUC24). RESULTS: Despite a fall in FBG of 0.65 mmol/L after 8 weeks, digits backward results correlated with FBG at both Week 0 and Week 8 (r=−0.43, P<0.01 and r=−0.32, P<0.01, respectively). Digits forward results correlated with FBG (r=−0.39, P<0.01), Gmax (r=−0.46, P<0.05), and AUC24 (r=−0.50, P<0.01) at Week 0 and FBG (r=−0.59, P<0.001), Gmax (r=0.37, P=0.01), AUC24 (r=−0.41, P<0.01), and percentage weight loss (r=0.31, P<0.01) at Week 8. Cognitive function was not altered by weight loss, gender, baseline lipid levels, or premorbid intelligence levels (National Adult Reading Test). CONCLUSIONS: FBG, Gmax, and AUC24 were related to cognitive function and an energy-restricted diet for 8 weeks did not alter this relationship. |
Keywords: | Humans Diabetes Mellitus, Type 2 Dietary Carbohydrates Blood Glucose Blood Glucose Self-Monitoring Monitoring, Physiologic Body Mass Index Diet, Reducing Fasting Analysis of Variance Cognition Glycemic Index Postprandial Period Adult Aged Middle Aged Australia Female Male |
Rights: | © Mary Ann Liebert |
DOI: | 10.1089/dia.2012.0143 |
Published version: | http://dx.doi.org/10.1089/dia.2012.0143 |
Appears in Collections: | Aurora harvest Medical Sciences publications |
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