Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/74926
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Type: Journal article
Title: Multivitamin supplementation improves nutritional status and bone quality in aged care residents
Author: Grieger, J.
Nowson, C.
Jarman, H.
Malon, R.
Ackland, L.
Citation: European Journal of Clinical Nutrition, 2009; 63(4):558-565
Publisher: Nature Publishing Group
Issue Date: 2009
ISSN: 0954-3007
1476-5640
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Responsibility: 
JA Grieger, CA Nowson, HF Jarman, R Malon and LM Ackland
Abstract: <h4>Objectives</h4>To assess the effectiveness of a multivitamin (MV) tablet on nutritional status, quantitative heel ultrasound (QUS), mobility, muscle strength and falls. The design comprised two groups matched on mobility levels, randomized to receive a daily MV or placebo (P) tablet for 6 months. The setting was an Australian residential care facility.<h4>Subjects</h4>A total of 92 aged care residents. Serum micronutrients, body weight, QUS, rate of falls, hand grip strength, and the timed up and go test were assessed at baseline and 6 months.<h4>Results</h4>A total of 49 participants consumed a MV and 43, a matched P for 6 months. There was a greater increase in the MV vs P group for serum 25(OH)D (mean difference+/-standard error, 33.4+/-2.6 nmol l(-1)), folate (13.4+/-2.8 nmol l(-1)), and vitamin B12 (178.0+/-40.3 pmol l(-1)) (all P<0.001). Adequate 25(OH)D concentrations (> or =50 nmol l(-1)) were found among 77% of participants in the MV group vs 10% taking P (P<0.001). Adjusting for baseline levels, the increase in QUS was greater in the MV vs P group (3.0+/-2.0 dB MHz(-1) vs -2.9+/-2.1 dB MHz(-1), respectively, P=0.041). There was a trend towards a 63% lower mean number of falls in the MV vs P group (0.3+/-0.1 falls vs 0.8+/-0.3 falls, P=0.078).<h4>Conclusions</h4>MV supplementation raised serum vitamin B12 and folate concentrations and increased serum 25(OH)D, which was accompanied by an apparent positive effect on bone density. We also found a trend towards a reduction in falls and this could contribute to a reduction in fractures.
Keywords: multivitamin; residential care; 25(OH)D; heel ultrasound
Rights: © 2009 Macmillan Publishers Limited
RMID: 0020122412
DOI: 10.1038/sj.ejcn.1602963
Appears in Collections:Molecular and Biomedical Science publications

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