Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator
Author: Hillman, M.
Gecz, J.
Citation: Journal of Human Genetics, 2001; 46(5):251-259
Publisher: Springer-Verlag Tokyo
Issue Date: 2001
ISSN: 1434-5161
Abstract: Expansion of the FRAXE CCG repeat to a full mutation is associated with methylation and transcriptional silencing of the FMR2 gene, and as a consequence, mild-to-borderline mental retardation. FMR2 is a member of a family of four proteins, AF4, LAF4, FMR2, and AF5q31. The proteins associated with this family localize to the cell nucleus. Various regions of FMR2, and each of the other members of the protein family, were cloned and analyzed for transcription activation in yeast and mammalian cells. In both yeast and mammalian cells, FMR2 showed strong transcription activation. AF4 activation potential was several-fold lower. Interestingly, isoforms of both FMR2 and LAF4 lacking exon 3 activated transcription better than the larger isoforms containing exon 3. Compared with the other members of the family, activation by FMR2 was the strongest. Our results show that FMR2 is a potent transcription activator and that its function is conserved. Elucidation of the function of the FMR2 protein as a transcription activator may place FMR2 within the molecular signalling pathways involved in nonspecific X-linked mental retardation (MRX).
Keywords: Hela Cells
Saccharomyces cerevisiae
Fragile X Syndrome
DNA-Binding Proteins
Nuclear Proteins
Transcriptional Elongation Factors
Alternative Splicing
Gene Transfer, Horizontal
Amino Acid Sequence
Molecular Sequence Data
Transcriptional Activation
DOI: 10.1007/s100380170074
Published version:
Appears in Collections:Aurora harvest
Paediatrics publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.