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|Title:||Recombinant microorganisms expressing an oligosaccharide receptor mimic|
|Contributor:||Townsend and Townsend and Crew|
|Invented by A. W. Paton, R. Morono, J. C. Paton; assigned to Women's and Children's Hospital, Adelaide Research & Innovation; Townsend and Townsend and Crew agents for inventors.|
|Abstract:||Chimeric carbohydrates produced by recombinant microorganism carrying exogenous glycosyl transferases act with or without exogenous enzymes required for synthesis or nucleotide synthesis precursors. These recombinant microorganism can be used as a means for competitively inhibiting the binding of toxins or adhesins to receptors of mucosal surfaces, especially gastrointestinal surface. In particular chimeric sugar moieties have been made for lipopolysaccharides, in recombinant microorganism that present multiple copies of the oligosaccharides. The oligosacchide moieties so presented act as receptor mimic for toxins and adhesins. A number have been synthesise and have been shown to confer protection against attack by pathogenic organisms or their products in vitro and an in vivo.|
|Keywords:||US 2005/0250196 A1|
|Description:||PATENT: A. W. Paton, R. Morono, J. C. Paton (Assignee: Women's and Children's Hospital, Adelaide Research & Innovation). US 2005/0250196 A1 filed Dec 20, 2004; published Nov 10, 2005 Registered under alternate title: Recombinant Bacterium expressing an oligosaccharide receptor mimic|
|Appears in Collections:||Molecular and Biomedical Science publications|
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