Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/75311
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Type: Journal article
Title: Efficacy and tolerability of pegylated interferon-α-2a in chronic hepatitis B: a multicenter clinical experience
Other Titles: Efficacy and tolerability of pegylated interferon-alpha-2a in chronic hepatitis B: a multicenter clinical experience
Author: Ratnam, D.
Dev, A.
Nguyen, T.
Sundararajan, V.
Harley, H.
Cheng, W.
Lee, A.
Rusli, F.
Chen, R.
Bell, S.
Pianko, S.
Sievert, W.
Citation: Journal of Gastroenterology and Hepatology, 2012; 27(9):1447-1453
Publisher: Blackwell Publishing Asia
Issue Date: 2012
ISSN: 0815-9319
1440-1746
Statement of
Responsibility: 
Dilip Ratnam, Anouk Dev, Tin Nguyen, Vijaya Sundararajan, Hugh Harley, Wendy Cheng, Alice Lee, Ferry Rusli, Robert Chen, Sally Bell, Stephen Pianko and William Sievert
Abstract: <h4>Background and aim</h4>Pegylated interferon-α (PEG-IFN) provides potential advantages over nucleos(t)ide analogues in the treatment of chronic hepatitis B (CHB) given its finite course, durability and lack of drug resistance. Much of the evidence is derived from controlled studies and it is unclear whether these results can be replicated in an everyday, non-controlled setting. The aim of this study was to examine the efficacy and tolerability of PEG-IFN-α2A in CHB patients in a clinical setting.<h4>Methods</h4>Chronic hepatitis B patients treated with PEG-IFN-α2A (180µg/week, 48 weeks) at five tertiary hospitals were retrospectively identified. Baseline demographic and clinical data, on-treatment virological and serological responses and adverse events (AE) were recorded. Treatment outcomes were defined as alanine aminotransferase (ALT) normalization, hepatitis B virus DNA <351 IU/mL and hepatitis B e antigen (HBeAg) seroconversion.<h4>Results</h4>Sixty three HBeAg positive patients were identified (65% male, 80% born in Asia, 84% with viral loads > 6log IU/mL, 9.5% advanced fibrosis). Six months after therapy 46% achieved normalization of ALT, 16% had viral loads < 351 IU/mL and 32% achieved HBeAg seroconversion. 29 HBeAg negative patients were treated (75% male, 86% born in Asia, 48% had viral loads > 6log IU/mL, 24% advanced fibrosis). Six months post-treatment, 55% and 36% maintained a normalized ALT and HBV DNA < 351 IU/mL, respectively. Optimal viral suppression was maintained in 50-75% of patients over 2 years of follow up. 6.5% of all patients discontinued therapy due to AEs.<h4>Conclusion</h4>In everyday clinical practice PEG-IFN therapy in CHB is well tolerated and can achieve a similar efficacy to that seen in large controlled trials.
Keywords: hepatitis B
anitviral therapy
pegylated interferon
viral hepatitis.
Rights: © 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
DOI: 10.1111/j.1440-1746.2011.07051.x
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