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https://hdl.handle.net/2440/75544
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Type: | Journal article |
Title: | Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? |
Author: | Kumar, S. |
Citation: | Nature Reviews Cancer, 2009; 9(12):897-903 |
Publisher: | Nature Publishing Group |
Issue Date: | 2009 |
ISSN: | 1474-175X 1474-1768 |
Statement of Responsibility: | Sharad Kumar |
Abstract: | Aberrations in proteins that control apoptosis and cell survival are common in cancer. These aberrations often reside in signalling proteins that control the activation of the apoptotic machinery or in the Bcl-2 family of proteins that control caspase activation. Recent evidence suggests that caspase 2, one of the most evolutionarily conserved caspases, may have multiple roles in the DNA damage response, cell cycle regulation and tumour suppression. These findings are unexpected and have important implications for our understanding of tumorigenesis and the treatment of cancer. |
Keywords: | Humans Neoplasms Cell Transformation, Neoplastic DNA Damage Signal Transduction Apoptosis Models, Biological Caspase 2 |
Rights: | © 2009 Macmillan Publishers Limited. All rights reserved |
DOI: | 10.1038/nrc2745 |
Published version: | http://dx.doi.org/10.1038/nrc2745 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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