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Type: Journal article
Title: Indomethacin treatment of infantile cortical periostosis in twins
Author: Couper, R.
McPhee, A.
Morris, L.
Citation: Journal of Paediatrics and Child Health, 2001; 37(3):305-308
Publisher: Blackwell Science Asia
Issue Date: 2001
ISSN: 1034-4810
Statement of
RTL Couper, A Mcphee and L Morris
Abstract: Twin girls presented with infantile cortical periostosis (Caffey's disease) at 2 and 3 weeks of age, respectively. This disorder initially involved their upper and lower limbs and resulted in fever, irritability and tenderness. X-rays showed extensive periosteal new bone formation. Multiple relapses occurred in the first year of life and during some of these relapses mandibular and clavicular involvement was noted. Prednisolone, 1 mg/kg per day, was used to treat relapses until 9 months of age. Indomethacin therapy at this age at a dose of 3 mg/kg per day allowed the cessation of prednisolone therapy and disease flares were thereafter infrequent and responsive to indomethacin.
Keywords: Bone
Caffey’s disease
infantile cortical periostosis
prostaglandin synthetase inhibitors
Description: The definitive version is available at
DOI: 10.1046/j.1440-1754.2001.00633.x
Appears in Collections:Aurora harvest 4
Paediatrics publications

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