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|Title:||Indomethacin treatment of infantile cortical periostosis in twins|
|Citation:||Journal of Paediatrics and Child Health, 2001; 37(3):305-308|
|Publisher:||Blackwell Science Asia|
|RTL Couper, A Mcphee and L Morris|
|Abstract:||Twin girls presented with infantile cortical periostosis (Caffey's disease) at 2 and 3 weeks of age, respectively. This disorder initially involved their upper and lower limbs and resulted in fever, irritability and tenderness. X-rays showed extensive periosteal new bone formation. Multiple relapses occurred in the first year of life and during some of these relapses mandibular and clavicular involvement was noted. Prednisolone, 1 mg/kg per day, was used to treat relapses until 9 months of age. Indomethacin therapy at this age at a dose of 3 mg/kg per day allowed the cessation of prednisolone therapy and disease flares were thereafter infrequent and responsive to indomethacin.|
infantile cortical periostosis
prostaglandin synthetase inhibitors
|Description:||The definitive version is available at www.blackwell-synergy.com|
|Appears in Collections:||Aurora harvest 4|
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