Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/75926
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Type: Journal article
Title: Protein interaction network of Arabidopsis thaliana female gametophyte development identifies novel proteins and relations
Author: Hosseinpour, B.
HajiHoseini, V.
Kashfi, R.
Ebrahimie, E.
Hemmatzadeh, F.
Citation: PLoS One, 2012; 7(12):1-12
Publisher: Public Library of Science
Issue Date: 2012
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Batool Hosseinpour, Vahid HajiHoseini, Rafieh Kashfi, Esmaeil Ebrahimie and Farhid Hemmatzadeh
Abstract: Although the female gametophyte in angiosperms consists of just seven cells, it has a complex biological network. In this study, female gametophyte microarray data from Arabidopsis thaliana were integrated into the Arabidopsis interactome database to generate a putative interaction map of the female gametophyte development including proteome map based on biological processes and molecular functions of proteins. Biological and functional groups as well as topological characteristics of the network were investigated by analyzing phytohormones, plant defense, cell death, transporters, regulatory factors, and hydrolases. This approach led to the prediction of critical members and bottlenecks of the network. Seventy-four and 24 upregulated genes as well as 171 and 3 downregulated genes were identified in subtracted networks based on biological processes and molecular function respectively, including novel genes such as the pathogenesis-related protein 4, ER type Ca2+ ATPase 3, dihydroflavonol reductase, and ATP disulfate isomerase. Biologically important relationships between genes, critical nodes, and new essential proteins such as AT1G26830, AT5G20850, CYP74A, AT1G42396, PR4 and MEA were found in the interactome’s network. The positions of novel genes, both upregulated and downregulated, and their relationships with biological pathways, in particular phytohormones, were highlighted in this study.
Keywords: Arabidopsis; Proteome; Transcription Factors; Oligonucleotide Array Sequence Analysis; Gene Expression Regulation, Plant; Germ Cells, Plant; Ovule; Protein Interaction Maps; Magnoliopsida
Rights: Copyright: © 2012 Hosseinpour et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020123542
DOI: 10.1371/journal.pone.0049931
Appears in Collections:Agriculture, Food and Wine publications

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