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https://hdl.handle.net/2440/7609
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dc.contributor.author | Omari, T. | - |
dc.contributor.author | Barnett, C. | - |
dc.contributor.author | Snel, A. | - |
dc.contributor.author | Davidson, G. | - |
dc.contributor.author | Haslam, R. | - |
dc.contributor.author | Bakewell, M. | - |
dc.contributor.author | Dent, J. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Journal of Pediatric Surgery, 1999; 34(12):1795-1798 | - |
dc.identifier.issn | 0022-3468 | - |
dc.identifier.issn | 1531-5037 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7609 | - |
dc.description.abstract | <h4>Background/purpose</h4>The aim of this study was to characterize the motor events responsible for gastroesophageal reflux (GER) and esophageal acid clearance in a cohort of preterm infants with chronic lung disease (CLD).<h4>Methods</h4>Esophageal motility was recorded for 2 to 3 hours postprandially in 14 preterm infants with mild-moderate or moderate-severe CLD at 33 to 39 weeks postmenstrual age using a sleeve-side hole micromanometric assembly into which a pH probe had been installed.<h4>Results</h4>Twenty-six acid GER episodes were recorded by pH probe. Of these, 22 (85%) were associated with transient lower esophageal sphincter (LES) relaxation. Transient LES relaxations were significantly longer in duration than single swallows (13.7 seconds v 4.6 seconds, P < .001) and had lower nadir pressures (1.1 mm Hg v 2.5 mm Hg, P < .001). During periods of esophageal acidification (pH below 4), peristaltic esophageal body pressure wave sequences cleared acid refluxate more effectively than nonperistaltic pressure wave sequences.<h4>Conclusions</h4>In preterm infants with CLD, transient LES relaxations are the predominant mechanism underlying GER, and esophageal clearance mechanisms are fully functional, which is similar to that seen in healthy preterm infants. | - |
dc.description.statementofresponsibility | T. Omari, C. Barnett, A. Snel, G. Davidson, R. Haslam, M. Bakewell, and J. Dent | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.rights | Copyright © 1999 Published by Elsevier Inc. | - |
dc.source.uri | http://dx.doi.org/10.1016/s0022-3468(99)90315-9 | - |
dc.subject | Chronic lung disease | - |
dc.subject | preterm neonate | - |
dc.subject | acid gastroesophageal reflux | - |
dc.subject | esophageal motility | - |
dc.subject | esophageal acid clearance | - |
dc.subject | transient lower esophageal sphincter relaxation. | - |
dc.title | Mechanism of gastroesophageal reflux in premature infants with chronic lung disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0022-3468(99)90315-9 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Omari, T. [0000-0001-5108-7378] | - |
dc.identifier.orcid | Barnett, C. [0000-0003-1717-3824] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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