Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7609
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dc.contributor.authorOmari, T.-
dc.contributor.authorBarnett, C.-
dc.contributor.authorSnel, A.-
dc.contributor.authorDavidson, G.-
dc.contributor.authorHaslam, R.-
dc.contributor.authorBakewell, M.-
dc.contributor.authorDent, J.-
dc.date.issued1999-
dc.identifier.citationJournal of Pediatric Surgery, 1999; 34(12):1795-1798-
dc.identifier.issn0022-3468-
dc.identifier.issn1531-5037-
dc.identifier.urihttp://hdl.handle.net/2440/7609-
dc.description.abstractBACKGROUND/PURPOSE:The aim of this study was to characterize the motor events responsible for gastroesophageal reflux (GER) and esophageal acid clearance in a cohort of preterm infants with chronic lung disease (CLD). METHODS:Esophageal motility was recorded for 2 to 3 hours postprandially in 14 preterm infants with mild-moderate or moderate-severe CLD at 33 to 39 weeks postmenstrual age using a sleeve-side hole micromanometric assembly into which a pH probe had been installed. RESULTS:Twenty-six acid GER episodes were recorded by pH probe. Of these, 22 (85%) were associated with transient lower esophageal sphincter (LES) relaxation. Transient LES relaxations were significantly longer in duration than single swallows (13.7 seconds v 4.6 seconds, P < .001) and had lower nadir pressures (1.1 mm Hg v 2.5 mm Hg, P < .001). During periods of esophageal acidification (pH below 4), peristaltic esophageal body pressure wave sequences cleared acid refluxate more effectively than nonperistaltic pressure wave sequences. CONCLUSIONS:In preterm infants with CLD, transient LES relaxations are the predominant mechanism underlying GER, and esophageal clearance mechanisms are fully functional, which is similar to that seen in healthy preterm infants.-
dc.description.statementofresponsibilityT. Omari, C. Barnett, A. Snel, G. Davidson, R. Haslam, M. Bakewell, and J. Dent-
dc.language.isoen-
dc.publisherW B SAUNDERS CO-ELSEVIER INC-
dc.rightsCopyright © 1999 Published by Elsevier Inc.-
dc.subjectChronic lung disease-
dc.subjectpreterm neonate-
dc.subjectacid gastroesophageal reflux-
dc.subjectesophageal motility-
dc.subjectesophageal acid clearance-
dc.subjecttransient lower esophageal sphincter relaxation.-
dc.titleMechanism of gastroesophageal reflux in premature infants with chronic lung disease-
dc.typeJournal article-
dc.identifier.doi10.1016/S0022-3468(99)90315-9-
pubs.publication-statusPublished-
dc.identifier.orcidOmari, T. [0000-0001-5108-7378]-
dc.identifier.orcidBarnett, C. [0000-0003-1717-3824]-
Appears in Collections:Aurora harvest
Paediatrics publications

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