Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76173
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Non-human primate dendritic cells
Author: Jesudason, S.
Collins, M.
Rogers, N.
Kireta, S.
Coates, P.
Citation: Journal of Leukocyte Biology, 2012; 91(2):217-228
Publisher: Federation Amer Soc Exp Biol
Issue Date: 2012
ISSN: 0741-5400
1938-3673
Statement of
Responsibility: 
Shilpanjali Jesudason, Michael G. Collins, Natasha M. Rogers, Svjetlana Kireta, and P. Toby H. Coates
Abstract: Non-human primates (NHP) are essential translational models for biomedical research. Dendritic cells (DC) are a group of antigen presenting cells (APC) that play pivotal roles in the immunobiology of health and disease and are attractive cells for adoptive immunotherapy to stimulate and suppress immunity. DC have been studied extensively in humans and mice but until recently, have not been well characterized in NHP. This review considers the available data about DC across a range of NHP species and summarizes the understanding of in vitro-propagated DC and in vivo-isolated DC, which is now established. It is clear that although NHP DC exist within the paradigm of human DC, there are important functional and phenotypic differences when compared with human DC subsets. These differences need to be taken into account when designing preclinical, translational studies of DC therapy using NHP models.
Keywords: in vitro propagation; growth factor mobilization; immunotherapy; translational research
Rights: © Society for Leukocyte Biology
RMID: 0020116748
DOI: 10.1189/jlb.0711355
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.