Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76325
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Type: Book chapter
Title: Experimental colitis models
Author: Hughes, P.
Brierley, S.
Castro Kraftchenko, J.
Harrington, A.
Blackshaw, L.
Citation: Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II, 2012 / Szallasi, A., Biro, T. (ed./s), pp.379-390
Publisher: Springer
Publisher Place: USA
Issue Date: 2012
Series/Report no.: Methods in Pharmacology and Toxicology
ISBN: 9781627030953
Statement of
Responsibility: 
Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington and L. Ashley Blackshaw
Abstract: Inflammatory Bowel Diseases (IBD) are life-threatening chronic and relapsing disorders of the immune system affecting the lower gastrointestinal tract. Despite the considerable efforts of many researchers, much remains to be learnt of their causes and appropriate treatment options. Crohn’s disease and ulcerative colitis comprise the majority of clinical IBD cases but differ considerably in terms of clinical representation and likely underlying mechanisms. As such, different animal models have been developed over the last 20 years to best characterize these diseases. It is widely accepted that DSS-induced colitis models ulcerative colitis, while TNBS induced colitis models Crohn’s disease. More recently, these models have been extended to investigate the mechanisms underlying the reciprocal regulation of the neuro-immune axis, both in times of acute inflammation and post-inflammation, with the latter modeling aspects of Irritable Bowel Syndrome. We describe the methodology involved in setting up, maintenance and evaluation of these two models of colitis, both of which are simply and economically achieved in a standard laboratory environment.
Keywords: Inflammatory Bowel Disease; Irritable Bowel Syndrome; TNBS; DSS; inflammation; sensory nerves
RMID: 0020123180
DOI: 10.1007/978-1-62703-095-3_23
Appears in Collections:Medicine publications

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