Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76325
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHughes, P.en
dc.contributor.authorBrierley, S.en
dc.contributor.authorCastro Kraftchenko, J.en
dc.contributor.authorHarrington, A.en
dc.contributor.authorBlackshaw, L.en
dc.date.issued2012en
dc.identifier.citationMethods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II, 2012 / Szallasi, A., Biro, T. (ed./s), pp.379-390en
dc.identifier.isbn9781627030953en
dc.identifier.urihttp://hdl.handle.net/2440/76325-
dc.description.abstractInflammatory Bowel Diseases (IBD) are life-threatening chronic and relapsing disorders of the immune system affecting the lower gastrointestinal tract. Despite the considerable efforts of many researchers, much remains to be learnt of their causes and appropriate treatment options. Crohn’s disease and ulcerative colitis comprise the majority of clinical IBD cases but differ considerably in terms of clinical representation and likely underlying mechanisms. As such, different animal models have been developed over the last 20 years to best characterize these diseases. It is widely accepted that DSS-induced colitis models ulcerative colitis, while TNBS induced colitis models Crohn’s disease. More recently, these models have been extended to investigate the mechanisms underlying the reciprocal regulation of the neuro-immune axis, both in times of acute inflammation and post-inflammation, with the latter modeling aspects of Irritable Bowel Syndrome. We describe the methodology involved in setting up, maintenance and evaluation of these two models of colitis, both of which are simply and economically achieved in a standard laboratory environment.en
dc.description.statementofresponsibilityPatrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington and L. Ashley Blackshawen
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofseriesMethods in Pharmacology and Toxicologyen
dc.subjectInflammatory Bowel Disease; Irritable Bowel Syndrome; TNBS; DSS; inflammation; sensory nervesen
dc.titleExperimental colitis modelsen
dc.typeBook chapteren
dc.identifier.rmid0020123180en
dc.identifier.doi10.1007/978-1-62703-095-3_23en
dc.publisher.placeUSAen
dc.identifier.pubid22479-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHughes, P. [0000-0001-7324-3626]en
dc.identifier.orcidBrierley, S. [0000-0002-2527-2905]en
dc.identifier.orcidCastro Kraftchenko, J. [0000-0002-5781-2224]en
dc.identifier.orcidHarrington, A. [0000-0002-1562-4137]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.