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Type: Journal article
Title: Pneumocystis carinii pneumonia in childhood systemic lupus erythematosus
Author: Foster, H.
Malleson, P.
Petty, R.
Roberton, D.
Cabral, D.
Citation: Journal of Rheumatology, 1996; 23(4):753-756
Issue Date: 1996
ISSN: 0315-162X
Abstract: <h4>Objective</h4>Although Pneumocystis carinii pneumonia (PCP) is known to occur in adults with systemic lupus erythematosus (SLE), this infection has rarely been described in childhood SLE. We describe 3 children with SLE who developed PCP and describe risk factors for this complication.<h4>Methods</h4>A retrospective case review.<h4>Results</h4>All 3 children had severe active SLE with organ involvement requiring immunosuppressive therapy, but the clinical presentations of PCP differed in each patient. They shared some of the known risk factors for opportunistic infection in adults with SLE, including lymphopenia, but severe lymphopenia (< 0.35 x 10(9)/1) was not seen.<h4>Conclusion</h4>PCP is an uncommon but serious complication of childhood SLE, and should be considered in the presence of respiratory symptoms, however subtle. The role of oral chemoprophylaxis is discussed.
Keywords: Lung
Pneumonia, Pneumocystis
Lupus Erythematosus, Systemic
Immunosuppressive Agents
Anti-Bacterial Agents
Fatal Outcome
Risk Factors
Retrospective Studies
Trimethoprim, Sulfamethoxazole Drug Combination
Appears in Collections:Aurora harvest 4
Paediatrics publications

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