Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7633
Type: Journal article
Title: Pneumocystis carinii pneumonia in childhood systemic lupus erythematosus
Author: Foster, H.
Malleson, P.
Petty, R.
Roberton, D.
Cabral, D.
Citation: Journal of Rheumatology, 1996; 23(4):753-756
Publisher: J RHEUMATOL PUBL CO
Issue Date: 1996
ISSN: 0315-162X
Abstract: <h4>Objective</h4>Although Pneumocystis carinii pneumonia (PCP) is known to occur in adults with systemic lupus erythematosus (SLE), this infection has rarely been described in childhood SLE. We describe 3 children with SLE who developed PCP and describe risk factors for this complication.<h4>Methods</h4>A retrospective case review.<h4>Results</h4>All 3 children had severe active SLE with organ involvement requiring immunosuppressive therapy, but the clinical presentations of PCP differed in each patient. They shared some of the known risk factors for opportunistic infection in adults with SLE, including lymphopenia, but severe lymphopenia (< 0.35 x 10(9)/1) was not seen.<h4>Conclusion</h4>PCP is an uncommon but serious complication of childhood SLE, and should be considered in the presence of respiratory symptoms, however subtle. The role of oral chemoprophylaxis is discussed.
Keywords: Lung; Humans; Pneumocystis; Pneumonia, Pneumocystis; Lupus Erythematosus, Systemic; Immunosuppressive Agents; Anti-Bacterial Agents; Fatal Outcome; Risk Factors; Retrospective Studies; Adolescent; Child; Female; Trimethoprim, Sulfamethoxazole Drug Combination
RMID: 0030005468
Appears in Collections:Paediatrics publications

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