Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76337
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dc.contributor.authorSchosser, A.en
dc.contributor.authorCohen-Woods, S.en
dc.contributor.authorGaysina, D.en
dc.contributor.authorChow, P.en
dc.contributor.authorMartucci, L.en
dc.contributor.authorFarmer, A.en
dc.contributor.authorKorszun, A.en
dc.contributor.authorGunasinghe, C.en
dc.contributor.authorGray, J.en
dc.contributor.authorJones, L.en
dc.contributor.authorCraddock, N.en
dc.contributor.authorOwen, M.en
dc.contributor.authorCraig, I.en
dc.contributor.authorMcGuffin, P.en
dc.date.issued2010en
dc.identifier.citationAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 2010; 153B(1):141-147en
dc.identifier.issn1552-4841en
dc.identifier.issn1552-485Xen
dc.identifier.urihttp://hdl.handle.net/2440/76337-
dc.description.abstractThe Neuregulin 1 (NRG1) gene was initially implicated in schizophrenia (SZ) and has recently been associated with bipolar disorder (BPD) in two studies. An association with major depressive disorder (MDD) has not yet been investigated but is warranted in view of the genetic overlap between MDD and BPD. We have performed a large-scale case-control study investigating the association between NRG1 polymorphisms and MDD, genotyping a selection of 14 single nucleotide polymorphisms (SNPs) spanning the NRG1 gene in a sample of 1,398 patients of White European ancestry with a diagnosis of MDD and 1,304 ethnically matched controls from three clinical sites in the UK. We found no single marker or haplotype associations that withstood correction for multiple testing. Our findings do not provide evidence that NRG1 plays a role in MDD or that this gene explains part of the genetic overlap with BPD.en
dc.description.statementofresponsibilityA. Schosser, S. Cohen-Woods, D. Gaysina, P.C. Chow, L. Martucci, A. Farmer, A. Korszun, C. Gunashinghe, J. Gray, L. Jones, N. Craddock, M.J. Owen, I.W. Craig, and P. McGuffinen
dc.language.isoenen
dc.publisherWiley-Lissen
dc.rightsCopyright © 2009 Wiley-Liss, Inc.en
dc.subjectNRG1; depression; association; affective disordersen
dc.titleNRG1 gene in recurrent major depression: No association in a large-scale case-control association studyen
dc.typeJournal articleen
dc.identifier.rmid0020124149en
dc.identifier.doi10.1002/ajmg.b.30965en
dc.identifier.pubid21947-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCohen-Woods, S. [0000-0003-2199-6129]en
Appears in Collections:Psychiatry publications

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