Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76389
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dc.contributor.authorCohen-Woods, S.en
dc.contributor.authorSchosser, A.en
dc.contributor.authorMcGuffin, P.en
dc.date.issued2009en
dc.identifier.citationActa Psychiatrica Scandinavica, 2009; 120(5):355-362en
dc.identifier.issn0001-690Xen
dc.identifier.issn1600-0447en
dc.identifier.urihttp://hdl.handle.net/2440/76389-
dc.description.abstractOBJECTIVE: Eric Strömgren was one of the pioneers of psychiatric genetics and family studies. There has now been an explosion of interest in this field and research progress, including linkage and association studies, whole genome genotyping, copy number variants and epigenetics is reviewed here. METHOD:  An overview of this area of psychiatric research is presented and discussed based on the relevant literature aiming at giving a recent status of the progress. RESULTS:  Broadly speaking linkage and association are complementary approaches used to locate genes contributing to the genetic aetiology of psychopathology. Linkage can be detected over comparatively large distances, however power is problematic when searching for quantitative trait loci with small effect sizes. In contrast, association studies can detect small effects but only over very small distances. Therefore, while several genome-wide linkage studies in psychiatric disorders have been performed, the majority of association studies have investigated specific functional candidate genes. CONCLUSION:  Due to very recent technological advancements, genome-wide association studies have now become possible and have identified some completely novel susceptibility loci. Other recent advances include the discovery of epigenetic phenomena and copy number variants.en
dc.description.statementofresponsibilityS. Cohen-Woods, A. Schosser and P. McGuffinen
dc.language.isoenen
dc.publisherBlackwell Munksgaarden
dc.rights© 2009 John Wiley & Sons A/Sen
dc.subjectFamily studies; twin studies; adoption studies; linkage; associationen
dc.titleFrom age correction to genome-wide associationen
dc.typeJournal articleen
dc.identifier.rmid0020124147en
dc.identifier.doi10.1111/j.1600-0447.2009.01465.xen
dc.identifier.pubid21948-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCohen-Woods, S. [0000-0003-2199-6129]en
Appears in Collections:Psychiatry publications

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