Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/76404
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Type: Journal article
Title: Cetuximab in metastatic colorectal cancer
Author: Broadbridge, V.
Karapetis, C.
Price, T.
Citation: Expert Review of Anticancer Therapy: an essential contribution to decision making in cancer care, 2012; 12(5):555-565
Publisher: Future Drugs Ltd.
Issue Date: 2012
ISSN: 1473-7140
1744-8328
Statement of
Responsibility: 
Vy Tuong Broadbridge, Cristos S. Karapetis and Timothy Jay Price
Abstract: Management of metastatic colorectal cancer has evolved in the last 10 years, with the availability of targeted therapies resulting in improvement in quality of life and overall survival. Cetuximab is a chimeric monoclonal antibody that binds to the EGF receptor, and the net effects are inhibition of tumor growth, invasion, angiogenesis and metastasis. Cetuximab binding to the EGF receptor is also known to augment the effects of chemotherapy and radiotherapy. Only tumors expressing wild-type KRAS respond to cetuximab and improvements in progression-free survival and overall survival are seen, whereas patients with mutant KRAS are considered to be resistant. Cetuximab is currently available worldwide for use as monotherapy or in combination with chemotherapy in first-, second- or third-line settings in metastatic colorectal cancer patients with wild-type KRAS.
Keywords: Humans
Colorectal Neoplasms
Liver Neoplasms
Camptothecin
ras Proteins
Proto-Oncogene Proteins
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Antibodies, Monoclonal
Mutation
Proto-Oncogene Proteins p21(ras)
Antibodies, Monoclonal, Humanized
ErbB Receptors
Cetuximab
Irinotecan
Rights: © 2012 Expert Reviews Ltd.
DOI: 10.1586/ERA.12.25
Appears in Collections:Aurora harvest
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