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|Title:||Tailoring morphological and interfacial properties of diatom silica microparticles for drug delivery applications|
|Citation:||Proceedings of CHEMECA 2012: quality of life through chemical engineering, held in Wellington, New Zealand, 23-26 September, 2012: pp.1635-1644|
|Conference Name:||CHEMECA (2012 : Wellington NZ)|
|Manpreet Bariana, Moom Sinn Aw and Dusan Losic|
|Abstract:||Nature has developed an elegant biologically based self-assembling synthetic route to produce silica biomaterials with complex 3-dimensional (3-d) porous structures, offering great potential to replace synthetic mesoporous materials as suitable drug carriers for the development of cost-effective drug delivery systems. This work presents the application of a diatomaceous earth (DE), naturally available silica, originated from fossilized phytoplankton as a potential substitute for synthetic materials used for drug delivery applications. The aim of this study is to explore the influence of particle size, morphology and surface modifications of diatom silica microparticles on their drug release properties. Raw diatomaceous earth (DE) material was purified and classified to obtain high purity DE silica porous particles with different size and shapes. Comparative scanning electron microscope and particle characterization confirmed their particle size including irregularly shaped silica particles (size 0.1-1 mum, classified as "fine"), mixed fractions (size 1-10mum, classified as "mixed") and pure unbroken DE structures (size 10- 15 mum, classified as "entire"). Surface modification of isolated DE with silanes and phosphonic acids were done using standard silanisation and phosphonation process. Water insoluble (indomethacin) and water soluble (gentamicin sulphate) drugs were loaded to study the release performances of modified DE particles. In-vitro drug release studies were performed over 1-4 weeks, to examine the impact of the particle size and hydrophilic/hydrophobic functional groups. Drug release studies showed a biphasic pattern, comprising of an initial burst release for 6 h, followed by zero order sustained release over 1-4 weeks. This study demonstrates the potential of silica DE particles as a natural carrier for water soluble and insoluble drugs with release controlled by their morphological and interfacial properties.|
|Keywords:||Drug delivery systems; chemical structure; spectrum analysis; surface chemistry|
|Rights:||© 2012 Engineers Australia|
|Appears in Collections:||Chemical Engineering publications|
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