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Type: Journal article
Title: Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder
Author: Cohen-Woods, S.
Gaysina, D.
Craddock, N.
Farmer, A.
Gray, J.
Gunasinghe, C.
Hoda, F.
Jones, L.
Knight, J.
Korszun, A.
Owen, M.
Sterne, A.
Craig, I.
McGuffin, P.
Citation: Human Molecular Genetics, 2009; 18(8):1504-1509
Publisher: Oxford Univ Press
Issue Date: 2009
ISSN: 0964-6906
Statement of
Sarah Cohen-Woods, Daria Gaysina, Nick Craddock, Anne Farmer, Joanna Gray, Cerisse Gunasinghe, Farzana Hoda, Lisa Jones, Jo Knight, Ania Korszun, Michael J. Owen, Abram Sterne, Ian W. Craig and Peter McGuffin
Abstract: It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024–rs2061174–rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case–control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.
Keywords: Humans
Receptor, Muscarinic M2
Case-Control Studies
Depressive Disorder
Middle Aged
Rights: © The Author 2009
DOI: 10.1093/hmg/ddp051
Grant ID: G0000647
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Psychiatry publications

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