Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76482
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dc.contributor.authorCohen-Woods, S.en
dc.contributor.authorGaysina, D.en
dc.contributor.authorCraddock, N.en
dc.contributor.authorFarmer, A.en
dc.contributor.authorGray, J.en
dc.contributor.authorGunasinghe, C.en
dc.contributor.authorHoda, F.en
dc.contributor.authorJones, L.en
dc.contributor.authorKnight, J.en
dc.contributor.authorKorszun, A.en
dc.contributor.authorOwen, M.en
dc.contributor.authorSterne, A.en
dc.contributor.authorCraig, I.en
dc.contributor.authorMcGuffin, P.en
dc.date.issued2009en
dc.identifier.citationHuman Molecular Genetics, 2009; 18(8):1504-1509en
dc.identifier.issn0964-6906en
dc.identifier.issn1460-2083en
dc.identifier.urihttp://hdl.handle.net/2440/76482-
dc.description.abstractIt has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024–rs2061174–rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case–control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.en
dc.description.statementofresponsibilitySarah Cohen-Woods, Daria Gaysina, Nick Craddock, Anne Farmer, Joanna Gray, Cerisse Gunasinghe, Farzana Hoda, Lisa Jones, Jo Knight, Ania Korszun, Michael J. Owen, Abram Sterne, Ian W. Craig and Peter McGuffinen
dc.language.isoenen
dc.publisherOxford Univ Pressen
dc.rights© The Author 2009en
dc.subjectHumans; Recurrence; Receptor, Muscarinic M2; Case-Control Studies; Depressive Disorder; Haplotypes; Middle Aged; Female; Maleen
dc.titleDepression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorderen
dc.typeJournal articleen
dc.identifier.rmid0020124155en
dc.identifier.doi10.1093/hmg/ddp051en
dc.identifier.pubid21944-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCohen-Woods, S. [0000-0003-2199-6129]en
Appears in Collections:Psychiatry publications

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