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Type: Journal article
Title: Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays
Author: Gulati, K.
Aw, M.
Findlay, D.
Losic, D.
Citation: Therapeutic Delivery, 2012; 3(7):857-873
Publisher: Future Science Ltd
Issue Date: 2012
ISSN: 2041-5990
Statement of
Karan Gulati, Moom Sinn Aw, David Findlay and Dusan Losic
Abstract: Titania nanotube (TNT) arrays fabricated by electrochemical anodization of titanium are currently one of the most attractive nanomaterials due to their remarkable properties. In this review, we highlight recent research activities that are focused on the application of the TNT arrays for local drug delivery, specifically for addressing problems associated with orthopedic implants. The advantages of drug-releasing implants based on TNT arrays for local delivery of therapeutics in bone related to these challenging problems including inflammation, infection and osseointegration are discussed. An overview of recent research to advance the drug-releasing performance of TNT arrays and the potential of their future applications and development are presented.
Keywords: Bone and Bones
Bone Diseases
Intercellular Signaling Peptides and Proteins
Anti-Inflammatory Agents
Biocompatible Materials
Drug Implants
Drug Carriers
Anti-Infective Agents
Technology, Pharmaceutical
Drug Compounding
Chemistry, Pharmaceutical
Rights: Copyright status unknown
DOI: 10.4155/tde.12.66
Appears in Collections:Aurora harvest
Chemical Engineering publications

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