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Type: Journal article
Title: Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays
Author: Gulati, K.
Aw, M.
Findlay, D.
Losic, D.
Citation: Therapeutic Delivery, 2012; 3(7):857-873
Publisher: Future Science Ltd
Issue Date: 2012
ISSN: 2041-5990
Statement of
Karan Gulati, Moom Sinn Aw, David Findlay and Dusan Losic
Abstract: Titania nanotube (TNT) arrays fabricated by electrochemical anodization of titanium are currently one of the most attractive nanomaterials due to their remarkable properties. In this review, we highlight recent research activities that are focused on the application of the TNT arrays for local drug delivery, specifically for addressing problems associated with orthopedic implants. The advantages of drug-releasing implants based on TNT arrays for local delivery of therapeutics in bone related to these challenging problems including inflammation, infection and osseointegration are discussed. An overview of recent research to advance the drug-releasing performance of TNT arrays and the potential of their future applications and development are presented.
Keywords: Bone and Bones; Animals; Humans; Bone Diseases; Titanium; Intercellular Signaling Peptides and Proteins; Anti-Inflammatory Agents; Biocompatible Materials; Drug Implants; Drug Carriers; Anti-Infective Agents; Technology, Pharmaceutical; Drug Compounding; Osseointegration; Chemistry, Pharmaceutical; Nanotubes; Nanomedicine
Rights: Copyright status unknown
RMID: 0020121480
DOI: 10.4155/tde.12.66
Appears in Collections:Chemical Engineering publications

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