Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76785
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dc.contributor.authorGaysina, D.en
dc.contributor.authorCohen-Woods, S.en
dc.contributor.authorCraddock, N.en
dc.contributor.authorFarmer, A.en
dc.contributor.authorHoda, F.en
dc.contributor.authorKorszun, A.en
dc.contributor.authorOwen, M.en
dc.contributor.authorCraig, I.en
dc.contributor.authorMcGuffin, P.en
dc.date.issued2008en
dc.identifier.citationAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 2008; 147B(6):699-706en
dc.identifier.issn1552-4841en
dc.identifier.issn1552-485Xen
dc.identifier.urihttp://hdl.handle.net/2440/76785-
dc.description.abstractUnipolar major depressive disorder (MDD) is a complex disorder thought to result from multiple genes in combination with environmental and developmental components. The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) has been implicated in MDD in a meta-analysis of association studies and is within a linkage region suggested by a recent study of affected sib pairs. A single base mutation in the MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme. The MTHFR 677TT genotype, and to a lesser extent the 677CT genotype, is associated with a significant elevation in the circulating concentrations of homocysteine and a decrease in serum folate concentrations. This may parallel a similar reduction in 5-methyltetrahydrofolate in the CNS, leading to a potential reduction in monoamine neurotransmitter function and an elevated risk of depressive disorder. To test the hypothesis that the MTHFR C677T polymorphism is involved in the predisposition to MDD, we conducted an association study of 1,222 patients with recurrent MDD and 835 control subjects. This allows 99% power to detect an effect of the size reported in the study of Bjelland et al. 2003, however no significant differences in genotype or allele frequencies between depressive patients and controls were observed. This was the case in the sample as a whole, and when females and males were considered separately. Our findings suggest that the MTHFR C677T polymorphism is not involved in the etiology of clinically significant recurrent MDD.en
dc.description.statementofresponsibilityD. Gaysina, S. Cohen, N. Craddock, A. Farmer, F. Hoda, A. Korszun, M.J. Owen, I.W. Craig and P. McGuffinen
dc.language.isoenen
dc.publisherWiley-Lissen
dc.rightsCopyright © 2007 Wiley-Liss, Inc.en
dc.subjectdepression; folate; association; meta-analysis; MTHFRen
dc.titleNo association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the Depression Case Control (DeCC) Study and a meta-analysisen
dc.typeJournal articleen
dc.identifier.rmid0020124119en
dc.identifier.doi10.1002/ajmg.b.30665en
dc.identifier.pubid21959-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCohen-Woods, S. [0000-0003-2199-6129]en
Appears in Collections:Psychiatry publications

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