Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76869
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Type: Journal article
Title: Improving the accuracy and comparability of model-based economic evaluations of health technologies for reimbursement decisions: a methodological framework for the development of reference models
Author: Hajiali Afzali, H.
Karnon, J.
Merlin, T.
Citation: Medical Decision Making, 2013; 33(3):325-332
Publisher: Hanley & Belfus Inc
Issue Date: 2013
ISSN: 0272-989X
1552-681X
Statement of
Responsibility: 
Hossein Haji Ali Afzali, Jonathan Karnon and Tracy Merlin
Abstract: Increasingly, decision analytic models are used within economic evaluations of health technologies (e.g., pharmaceuticals) submitted to national reimbursement bodies in countries like Australia and UK, where such models play a fundamental role in informing public funding decisions. Concerns regarding the accuracy of model outputs and hence the credibility of national reimbursement decisions are frequently raised. We propose a framework for developing reference models for specific diseases to inform economic evaluations of health technologies and their appraisal. The structure of a reference model reflects the natural history of the condition under study and defines the clinical events to be represented, the relationships between the events, and the effect of patient characteristics on the probability and timing of events. We contend that the use of reference models will improve the accuracy and comparability of public funding decisions. This can lead to the more efficient allocation of public funds.
Keywords: Modle uncertainty; sensitivity analysis; reference model
Rights: Copyright © 2013 by Society for Medical Decision Making
RMID: 0020126046
DOI: 10.1177/0272989X12458160
Appears in Collections:Public Health publications

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