Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/77000
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCundy, T.en
dc.contributor.authorAntoniou, G.en
dc.contributor.authorSutherland, L.en
dc.contributor.authorFreeman, B.en
dc.contributor.authorCundy, P.en
dc.date.issued2013en
dc.identifier.citationSpine, 2013; 38(7):564-570en
dc.identifier.issn0362-2436en
dc.identifier.issn1528-1159en
dc.identifier.urihttp://hdl.handle.net/2440/77000-
dc.description.abstractSTUDY DESIGN. A prospective cohort study. OBJECTIVE. To determine serum titanium, niobium, and aluminum levels in pediatric patients within the first postoperative year after instrumented spinal arthrodesis. SUMMARY OF BACKGROUND DATA. Instrumented spinal arthrodesis is a common procedure to correct scoliosis and kyphosis. Titanium-based instrumentation is increasingly favored due to enhanced biomechanical properties, but concerns have arisen regarding metal debris release and the potential for local and systemic complications. METHODS. The pattern of systemic metal release over time was evaluated by measuring serum titanium, niobium, and aluminum levels preoperatively and 1 week, 1 month, 6 months, and 12 months after instrumented spinal arthrodesis using a titanium alloy. Serum metal levels were measured using high-resolution inductively coupled plasma mass spectrometry. RESULTS. Thirty-two patients were included in the study group. Mean age at surgery was 14.7 years. Preoperative and postoperative concentrations of serum titanium and niobium were significantly different (P = 0.0001). Median postoperative serum concentrations of titanium and niobium were elevated 2.4- and 5.9-fold above the normal range respectively with 95% and 99% of samples elevated postoperatively. A significant and rapid rise in serum titanium and niobium levels was observed within the first postoperative week, after which elevated serum levels persisted up to 12 months. CONCLUSION. We report abnormally elevated serum titanium and niobium levels in patients with titanium-based spinal instrumentation up to 12 months. The long-term systemic consequences of debris generated by wear and corrosion of spinal instrumentation is unclear but concerning, particularly as these implants inserted into the pediatric population may remain in situ for beyond 6 decades.en
dc.description.statementofresponsibilityThomas P. Cundy, Georgia Antoniou, Leanne M. Sutherland, Brian J.C. Freeman and Peter J. Cundyen
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.rights© 2013, Lippincott Williams & Wilkinsen
dc.subjectHumans; Kyphosis; Scoliosis; Niobium; Aluminum; Titanium; Alloys; Spinal Fusion; Postoperative Period; Prospective Studies; Internal Fixators; Adolescent; Child; Female; Maleen
dc.titleSerum titanium, niobium, and aluminum levels after instrumented spinal arthrodesis in childrenen
dc.typeJournal articleen
dc.identifier.rmid0020126313en
dc.identifier.doi10.1097/BRS.0b013e3182741961en
dc.identifier.pubid20792-
pubs.library.collectionOrthopaedics and Trauma publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCundy, T. [0000-0002-3884-2567]en
dc.identifier.orcidSutherland, L. [0000-0002-7822-3189]en
dc.identifier.orcidFreeman, B. [0000-0003-0237-9707]en
dc.identifier.orcidCundy, P. [0000-0002-8050-6153]en
Appears in Collections:Orthopaedics and Trauma publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.