Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres
Author: Popat, A.
Ross, B.
Liu, J.
Jambhrunkar, S.
Kleitz, F.
Qiao, S.
Citation: Angewandte Chemie International Edition, 2012; 51(50):12486-12489
Publisher: Wiley-V C H Verlag GMBH
Issue Date: 2012
ISSN: 1433-7851
Statement of
Amirali Popat, Benjamin P. Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, and Shi Zhang Qiao
Abstract: I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.
Keywords: azo-reductase
colon targeting
drug delivery
Rights: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/anie.201206416
Grant ID:
Published version:
Appears in Collections:Aurora harvest
Chemical Engineering publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.