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Type: Conference paper
Title: Single grating x-ray imaging for dynamic biological systems
Author: Morgan, K.
Paganin, D.
Parsons, D.
Donnelly, M.
Yagi, N.
Uesugi, K.
Suzuki, Y.
Takeuchi, A.
Siu, K.
Citation: International Workshop on X-Ray and Neutron Phase Imaging with Gratings, 2012 / vol.1466, pp.124-129
Publisher: Springer New York LLC
Publisher Place: United States
Issue Date: 2012
Series/Report no.: AIP Conference Proceedings
ISBN: 9780735410725
ISSN: 0094-243X
Conference Name: International Workshop on X-Ray and Neutron Phase Imaging with Gratings (05 Mar 2012 - 07 Mar 2012 : Tokyo, Japan)
Statement of
Kaye S. Morgan, David M. Paganin, David W. Parsons, Martin Donnelley, Naoto Yagi, Kentaro Uesugi, Yoshio Suzuki, Akihisa Takeuchi and Karen K.W. Siu
Abstract: Biomedical studies are already benefiting from the excellent contrast offered by phase contrast x-ray imaging, but live imaging work presents several challenges. Living samples make it particularly difficult to achieve high resolution, sensitive phase contrast images, as exposures must be short and cannot be repeated. We therefore present a single-exposure, high-flux method of differential phase contrast imaging [1, 2, 3] in the context of imaging live airways for Cystic Fibrosis (CF) treatment assessment [4]. The CF study seeks to non-invasively observe the liquid lining the airways, which should increase in depth in response to effective treatments. Both high spatial resolution and sensitivity are required in order to track micron size changes in a liquid that is not easily differentiated from the tissue on which it lies. Our imaging method achieves these goals by using a single attenuation grating or grid as a reference pattern, and analyzing how the sample deforms the pattern to quantitatively retrieve the phase depth of the sample. The deformations are mapped at each pixel in the image using local cross-correlations comparing each ‘sample and pattern’ image with a reference ‘pattern only’ image taken before the sample is introduced. This produces a differential phase image, which may be integrated to give the sample phase depth.
Keywords: Phase contrast x-ray imaging; biomedical imaging; synchrotron imaging Cystic Fibrosis; airways
Rights: © 2012 American Institute of Physics
RMID: 0020126322
DOI: 10.1063/1.4742280
Appears in Collections:Paediatrics publications

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