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Type: Book chapter
Title: Magnesium in acute brain injury
Author: Turner, R.
Corrigan, F.
Vink, R.
Citation: Metal Ion in Stroke, 2012 / Li, Y., Zhang, J. (ed./s), pp.445-460
Publisher: Springer
Publisher Place: United States
Issue Date: 2012
Series/Report no.: Springer Series in Translational Stroke Research
ISBN: 9781441996626
Editor: Li, Y.
Zhang, J.
Statement of
Renée J. Turner, Frances Corrigan and Robert Vink
Abstract: Acute injury to the central nervous system, such as stroke and traumatic brain injury (TBI), is a leading cause of morbidity and mortality, and represents a significant public health issue worldwide. Despite extensive pre-clinical investigation, few therapeutic treatment options are available to patients meaning that severe disability and requirement of long-term rehabilitation are common outcomes. The majority of the damage that occurs following stroke and TBI is initiated by the primary injury and develops over time. Such secondary injury encompasses a number of damaging biochemical and pathophysiological events. However, the delayed nature of such injury provides an opportunity for therapeutic intervention. Indeed, magnesium decline has been identified as a key secondary injury process, one that is associated with significant functional impairment. Magnesium administration has been extensively evaluated in both experimental and clinical stroke and TBI with varied success. This chapter focuses on the role of magnesium in TBI and stroke pathophysiology, with particular emphasis on magnesium as a potential therapeutic agent.
Keywords: Magnesium
traumatic brain injury
DOI: 10.1007/978-1-4419-9663-3_22
Appears in Collections:Aurora harvest 4
Medical Sciences publications

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