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dc.contributor.authorGupta, A.en
dc.contributor.authorPrabhakaran, V.en
dc.contributor.authorDodd, T.en
dc.contributor.authorDavis, G.en
dc.contributor.authorSelva-Nayagam, D.en
dc.identifier.citationOrbit, 2012; 31(6):386-389en
dc.description.abstractBackground/Aims: Immunohistochemical characterisation of orbital cavernous haemangiomas (CHs) with respect to proliferative capacity, hormone receptor status and vascular differentiation. Methods: Eleven cases of orbital CHs were reviewed. Immunohistochemical stains for Mib-1, proliferating cell nuclear antigen (PCNA), Bcl-2, estrogen and progesterone receptors (ER & PR), CD31, D2-40, and VEGF were investigated in 11 specimens. Results: Immunohistochemical staining revealed positivity for PCNA in ten of the 11 cases (91%). Bcl-2 was positive in 8 cases (73%). VEGF and PR were each weakly positive in 3 cases. All cases were negative for Mib-1, ER and D2-40. The staining was localized around the endothelium. Conclusion: This is the first study to characterise in detail the immunohistochemical features of orbital CHs. The proliferative markers PCNA and Mib-1 show discordant expression in these lesions and the expression of PCNA and Bcl-2 in the absence of Mib-1 is indicative of low proliferative potential. Small subsets of these tumors express PR and VEGF, which may partly explain the proliferative capacity of some orbital CHs.en
dc.description.statementofresponsibilityAanchal Gupta, Venkatesh C. Prabhakaran, Tom Dodd, Garry Davis, and Dinesh Selvaen
dc.publisherTaylor & Francis The Netherlandsen
dc.rights© 2012 Informa Healthcare USA, Inc.en
dc.subjectCavernous haemangioma; Immunohistochemistry; Differentiation; Proliferationen
dc.titleOrbital cavernous haemangiomas: immunohistochemical study of proliferative capacity, vascular differentiation and hormonal receptor statusen
dc.typeJournal articleen
pubs.library.collectionOpthalmology & Visual Sciences publicationsen
dc.identifier.orcidSelva-Nayagam, D. [0000-0002-2169-5417]en
Appears in Collections:Opthalmology & Visual Sciences publications

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