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https://hdl.handle.net/2440/77439
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Type: | Journal article |
Title: | Orbital cavernous haemangiomas: immunohistochemical study of proliferative capacity, vascular differentiation and hormonal receptor status |
Author: | Gupta, A. Prabhakaran, V. Dodd, T. Davis, G. Selva-Nayagam, D. |
Citation: | Orbit: the international journal on orbital disorders, oculoplastic and lacrimal surgery, 2012; 31(6):386-389 |
Publisher: | Taylor & Francis The Netherlands |
Issue Date: | 2012 |
ISSN: | 0167-6830 1744-5108 |
Statement of Responsibility: | Aanchal Gupta, Venkatesh C. Prabhakaran, Tom Dodd, Garry Davis, and Dinesh Selva |
Abstract: | Background/Aims: Immunohistochemical characterisation of orbital cavernous haemangiomas (CHs) with respect to proliferative capacity, hormone receptor status and vascular differentiation. Methods: Eleven cases of orbital CHs were reviewed. Immunohistochemical stains for Mib-1, proliferating cell nuclear antigen (PCNA), Bcl-2, estrogen and progesterone receptors (ER & PR), CD31, D2-40, and VEGF were investigated in 11 specimens. Results: Immunohistochemical staining revealed positivity for PCNA in ten of the 11 cases (91%). Bcl-2 was positive in 8 cases (73%). VEGF and PR were each weakly positive in 3 cases. All cases were negative for Mib-1, ER and D2-40. The staining was localized around the endothelium. Conclusion: This is the first study to characterise in detail the immunohistochemical features of orbital CHs. The proliferative markers PCNA and Mib-1 show discordant expression in these lesions and the expression of PCNA and Bcl-2 in the absence of Mib-1 is indicative of low proliferative potential. Small subsets of these tumors express PR and VEGF, which may partly explain the proliferative capacity of some orbital CHs. |
Keywords: | Cavernous haemangioma Immunohistochemistry Differentiation Proliferation |
Rights: | © 2012 Informa Healthcare USA, Inc. |
DOI: | 10.3109/01676830.2012.711887 |
Published version: | http://dx.doi.org/10.3109/01676830.2012.711887 |
Appears in Collections: | Aurora harvest Opthalmology & Visual Sciences publications |
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