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https://hdl.handle.net/2440/7758
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Type: | Journal article |
Title: | Gamma-Heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation |
Author: | Liu, X. Baker, E. Eyre, H. Sutherland, G. Zhou, M. |
Citation: | Oncogene, 1999; 18(50):7110-7114 |
Publisher: | NATURE PUBLISHING GROUP |
Issue Date: | 1999 |
ISSN: | 0950-9232 1476-5594 |
Statement of Responsibility: | Xifu Liu, Elizabeth Baker, Helen J Eyre, Grant R Sutherland and Mingdong Zhou |
Abstract: | gamma-Heregulin was identified as an isoform resulting from alternate splicing of the neuregulin-1 gene, after cloning of its cDNA from the MDA-MB-175 breast cancer cell line. gamma-Heregulin was shown to promote growth of cultured MDA-MB-175 cells resulting from activation of its cognate ErbB tyrosine kinase reporters. We show here that gamma-heregulin is transcribed from a fusion gene resulting from a chromosome translocation in MDA-MB-175 cells. The fusion chromosome is described as dic(8:11)(8qter-->8p12::11q13-->11pter). As a result, the 5' end of the gamma-heregulin gene is derived from the stress-induced gene, DOC-4 (11q13), while the 3' end is from the neuregulin-1 gene (8p12). Thus, expression of gamma-heregulin is under the control of the DOC-4 promoter. By contrast with MDA-MB-175 cells, RT-PCR failed to detect a gamma-heregulin transcript in either E9.5 to E13.5 embryonic mouse tissues, adult mouse tissues or other human tumour cell lines. We conclude, therefore, that gamma-heregulin is not a native isoform of the neuregulin-1 gene, but a novel growth factor that may contribute to tumour cell proliferation. |
Keywords: | gamma-heregulin neuregulin-1 DOC-4 gene localization MDA-MB-175 cell line |
DOI: | 10.1038/sj.onc.1203136 |
Published version: | http://dx.doi.org/10.1038/sj.onc.1203136 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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