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|Title:||GM-CSF-induced priming of human neutrophils for enhanced phagocytosis and killing of asexual blood stages of Plasmodium falciparum: synergistic effects of GM-CSF and TNF|
|Citation:||Parasite Immunology, 1996; 18(3):115-123|
|Lakshmi M. Kumaratilake, Antonio Ferrante, Timothy Jaeger & Christine Rzepczyk|
|Abstract:||Granulocyte macrophage-colony stimulation factor (GM-CSF), which is a haematopoietic cytokine generated by activated T lymphocytes and macrophages during infection, was investigated for its effects on human neutrophil-mediated killing of asexual blood forms of Plasmodium falciparum. Pretreatment of neutrophils with human recombinant-GM-CSF markedly increased the parasite killing (measured by a radiometric assay), in the presence of normal serum (containing complement), immune serum (IS), purified IgG (from IS) or heat inactivated IS. GM-CSF pretreatment also enhanced phagocytosis of the parasite by neutrophils and the expression of CR3, FcγRII and FcγRIII receptors. Treatment of neutrophils with a combination of GM-CSF and TNF resulted in a synergistic increase in phagocytosis and killing of the parasite. The findings suggest that GM-CSF is likely to form part of the cytokine network responsible for regulating the antiparasitic activity of the neutrophil in malaria.|
|Keywords:||Malaria; neutrophils; phagocytosis; GM-CSF; TNF|
|Description:||Article first published online: 31 OCT 2003|
|Rights:||© 1996 Blackwell Science Ltd.|
|Appears in Collections:||Aurora harvest|
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