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Type: Journal article
Title: IgG4-related orbital disease: a meta-analysis and review
Author: Andrew, N.
Kearney, D.
Selva-Nayagam, D.
Citation: Acta Ophthalmologica, 2012; online(8):1-7
Publisher: Wiley-Blackwell Munksgaard
Issue Date: 2012
ISSN: 1755-375X
Statement of
Nicholas Andrew, Daniel Kearney and Dinesh Selva
Abstract: IgG4-related orbital disease (IgG4-ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta-analysis of published cases and reveals several differences between IgG4-related disease affecting the orbit and that affecting the pancreas. IgG4-ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non-Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.
Keywords: dacryoadenitis; IgG4; IgG4-related disease; IgG4-related orbital disease; orbital; review
Rights: © 2012 The Authors.
RMID: 0020127353
DOI: 10.1111/j.1755-3768.2012.02526.x
Appears in Collections:Opthalmology & Visual Sciences publications

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