Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7802
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dc.contributor.authorZola, H.en
dc.contributor.authorFusco, M.en
dc.contributor.authorMacardle, P.en
dc.contributor.authorFlego, L.en
dc.contributor.authorRoberton, D.en
dc.date.issued1995en
dc.identifier.citationPediatric Research, 1995; 38(3):397-403en
dc.identifier.issn0031-3998en
dc.identifier.issn1530-0447en
dc.identifier.urihttp://hdl.handle.net/2440/7802-
dc.description.abstractThe expression of receptors for several cytokines (IL 2, IL-4, IL-6, IL-7, tumor necrosis factor, and interferon-gamma) was examined in human cord blood cells in comparison with adult blood cells. A previously described high sensitivity immunofluorescence procedure was used to render the low levels of receptor measurable. Cord blood lymphocytes expressed measurable levels of most cytokine receptors, but expression tended to be lower than in adult blood cells. Examination of different lymphocyte subpopulations revealed a complex pattern with some cell types expressing particular receptors equivalent to adult levels. Cord and adult blood monocytes expressed similar cytokine receptor profiles. Receptor expression in cord lymphocytes could be regulated by activation. The results provide indications as to the relative activities of different cytokines in the development of the immune system in the neonate.en
dc.language.isoenen
dc.publisherS. Kargeren
dc.subjectLymphocytes; Monocytes; Cells, Cultured; Fetal Blood; Humans; Phytohemagglutinins; Receptors, Cytokine; Interleukin-4; Antibodies, Monoclonal; Flow Cytometry; Lymphocyte Activation; Adult; Infant, Newbornen
dc.titleExpression of cytokine receptors by human cord blood lymphocytes: comparison with adult blood lymphocytesen
dc.typeJournal articleen
dc.identifier.rmid0030005401en
dc.identifier.doi10.1203/00006450-199509000-00021en
dc.identifier.pubid69407-
pubs.library.collectionPaediatrics publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Paediatrics publications

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