Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/78046
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dc.contributor.author | Khew-Goodall, Y. | - |
dc.contributor.author | Goodall, G. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Nature Cell Biology, 2012; 14(2):124-125 | - |
dc.identifier.issn | 1465-7392 | - |
dc.identifier.issn | 1476-4679 | - |
dc.identifier.uri | http://hdl.handle.net/2440/78046 | - |
dc.description.abstract | Cancer-associated fibroblasts contribute to malignancy by expressing secreted pro-tumorigenic molecules. The microRNA miR-320 is now shown to be a crucial component of a PTEN-controlled tumour-suppressive axis in stromal fibroblasts. Loss of PTEN and miR-320 induces an oncogenic secretome that reprogrammes the tumour microenvironment to promote invasion and angiogenesis. | - |
dc.description.statementofresponsibility | Yeesim Khew-Goodall and Gregory J. Goodall | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2012 Macmillan Publishers Limited. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1038/ncb2431 | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | MicroRNAs | - |
dc.subject | Gene Expression Profiling | - |
dc.subject | Gene Expression Regulation, Neoplastic | - |
dc.subject | Female | - |
dc.subject | PTEN Phosphohydrolase | - |
dc.subject | Tumor Microenvironment | - |
dc.title | Stromal miR-320 keeps an oncogenic secretome in check | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/ncb2431 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Khew-Goodall, Y. [0000-0002-0473-5392] | - |
dc.identifier.orcid | Goodall, G. [0000-0003-1294-0692] | - |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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