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|Title:||Osteocyte apoptosis and lipid infiltration as mechanisms of alcohol-induced bone loss|
|Citation:||Alcohol and Alcoholism, 2012; 47(4):413-422|
|Publisher:||Oxford Univ Press|
|Delphine B. Maurel, Stéphane Pallu, Christelle Jaffré, Nicola L. Fazzalari, Nathalie Boisseau, Rustem Uzbekov, Claude-Laurent Benhamou and Gaël Y. Rochefort|
|Abstract:||AIMS: We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss. METHODS AND RESULTS: After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels. CONCLUSION: These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or ‘bone steatosis’, is correlated with lipid accumulation in bone marrow and blood micro-vessels.|
|Keywords:||Bone Marrow Cells; Osteocytes; Animals; Rats; Rats, Wistar; Bone Diseases, Metabolic; Ethanol; Lipids; Microscopy, Electron, Transmission; Apoptosis; Bone Density; Male; Adiposity|
|Rights:||© The Author 2012. Medical Council on Alcohol and Oxford University Press. All rights reserved|
|Appears in Collections:||Anatomical Sciences publications|
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