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Type: Journal article
Title: Osteocyte apoptosis and lipid infiltration as mechanisms of alcohol-induced bone loss
Author: Maurel, D.
Pallu, S.
Jaffre, C.
Fazzalari, N.
Boisseau, N.
Uzbekov, R.
Benhamou, C.
Rochefort, G.
Citation: Alcohol and Alcoholism, 2012; 47(4):413-422
Publisher: Oxford Univ Press
Issue Date: 2012
ISSN: 0735-0414
Statement of
Delphine B. Maurel, Stéphane Pallu, Christelle Jaffré, Nicola L. Fazzalari, Nathalie Boisseau, Rustem Uzbekov, Claude-Laurent Benhamou and Gaël Y. Rochefort
Abstract: AIMS: We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss. METHODS AND RESULTS: After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels. CONCLUSION: These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or ‘bone steatosis’, is correlated with lipid accumulation in bone marrow and blood micro-vessels.
Keywords: Bone Marrow Cells; Osteocytes; Animals; Rats; Rats, Wistar; Bone Diseases, Metabolic; Ethanol; Lipids; Microscopy, Electron, Transmission; Apoptosis; Bone Density; Male; Adiposity
Rights: © The Author 2012. Medical Council on Alcohol and Oxford University Press. All rights reserved
RMID: 0020120576
DOI: 10.1093/alcalc/ags057
Appears in Collections:Anatomical Sciences publications

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