Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/781
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Colby, C. | - |
dc.contributor.author | O'Neill, B. | - |
dc.contributor.author | Middelberg, A. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Biotechnology Progress, 1996; 12(1):92-99 | - |
dc.identifier.issn | 8756-7938 | - |
dc.identifier.uri | http://hdl.handle.net/2440/781 | - |
dc.description.abstract | Using a modified version of the volume-averaged continuum theory for multiphase processes, theoretical predictions of pressure drop across compressible packed beds of Sepharose Big-Beads SP (Amrad Pharmacia Biotech, Sydney, Australia) are made. Modifications to the volume-averaged continuum theory included an additional term incorporated into governing equations to account for the influence of column diameter and a constitutive function to account for the effect of compressibility on pressure gradient. Theoretical predictions are compared to experimental pressure-drop data. Results indicate the modified volume-averaged continuum theory can provide accurate pressure-drop predictions for Sepharose Big-Beads SP at different bed heights, column diameters, superficial velocities, and fluid viscosity. The influence of column diameter on pressure-drop behavior during scale-up is then examined by comparing theoretical predictions for laboratory and production-scale columns. Predictions demonstrate a significant dependence on column diameter. This result emphasizes the dangers of predicting pressure-drop behavior for compressible chromatography resins in production-scale columns by extrapolation from laboratory-scale pressure-drop data. | - |
dc.description.statementofresponsibility | Christopher B. Colby, Brian K. O’Neill, and Anton P. J. Middelberg | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | Copyright © 1996 American Institute of Chemical Engineers (AIChE) | - |
dc.source.uri | http://dx.doi.org/10.1021/bp950029k | - |
dc.title | A modified version of the volume-averaged continuum theory to predict pressure drop across compressible packed beds of Sepharose Big-beads SP | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1021/bp950029k | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Chemical Engineering publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.