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Type: Journal article
Title: Functional neuroimaging demonstrates that ghrelin inhibits the central nervous system response to ingested lipid
Author: Jones, R.
McKie, S.
Astbury, N.
Little, T.
Tivey, S.
Lassman, D.
McLaughlin, J.
Luckman, S.
Williams, S.
Dockray, G.
Thompson, D.
Citation: Gut, 2012; 61(11):1543-1551
Publisher: British Med Journal Publ Group
Issue Date: 2012
ISSN: 0017-5749
Statement of
Richard B Jones, Shane McKie, Nerys Astbury, Tanya J Little, Stacey Tivey, Daniel J Lassman, John McLaughlin, Simon Luckman, Steve R Williams, Graham J Dockray, David G Thompson
Abstract: Objective: Gut-derived humoural factors activate central nervous system (CNS) mechanisms controlling energy intake and expenditure, and autonomic outflow. Ghrelin is secreted from the stomach and stimulates food intake and gastric emptying, but the relevant mechanisms are poorly understood. Nutrient-activated CNS systems can be studied in humans by physiological/pharmacological MRI (phMRI). This method has been used to examine the CNS responses to exogenous ghrelin. Design: phMRI was used to study the CNS responses in healthy people to a ghrelin bolus (0.3 nmol/kg, intravenous) in the post-prandial state, and an intravenous infusion of ghrelin (1.25 pmol/kg/min) alone and after intragastric lipid (dodecanoate, C12) in people who have fasted. Results: A ghrelin bolus decreased the blood oxygenation level dependent (BOLD) signal detected by phMRI in feeding-activated areas of the CNS in the post-prandial state. Infusion of ghrelin reversed the effect of C12 in delaying gastric emptying but had no effect on hunger. Intragastric C12 caused strong bilateral activation of a matrix of CNS areas, including the brain stem, hypothalamus and limbic areas which was attenuated by exogenous ghrelin. Ghrelin infusion alone had a small but significant stimulatory effect on CNS BOLD signals. Conclusion: Ghrelin inhibits activation of the hypothalamus and brain stem induced by ingested nutrients, suggesting a role in suppression of gut-derived satiety signals in humans.
Keywords: Central Nervous System
Magnetic Resonance Imaging
Body Mass Index
Infusions, Intravenous
Sensitivity and Specificity
Cohort Studies
Gastric Emptying
Postprandial Period
Dose-Response Relationship, Drug
Reference Values
Middle Aged
Lipid Metabolism
Young Adult
Functional Neuroimaging
Rights: Copyright status unknown
DOI: 10.1136/gutjnl-2011-301323
Appears in Collections:Aurora harvest 4
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