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Type: Journal article
Title: A molecular survey of a captive wallaby population for periodontopathogens and the co-incidence of Fusobacterium necrophorum subspecies necrophorum with periodontal diseases
Author: Antiabong, J.
Boardman, W.
Smith, I.
Brown, M.
Ball, A.
Goodman, A.
Citation: Veterinary Microbiology, 2013; 163(3-4):335-343
Publisher: Elsevier Science BV
Issue Date: 2013
ISSN: 0378-1135
Statement of
John F. Antiabong, Wayne Boardman, Ian Smith, Melissa H. Brown, Andrew S. Ball, Amanda E. Goodman
Abstract: Periodontal diseases (PD) are diseases of polymicrobial aetiology and constitute major health problems in captive macropods. Increasing knowledge of the causal pathogens is therefore crucial for effective management and prevention of these diseases. PCR survey and sequence analyses of potential periodontopathogens in captive wallaby populations revealed a co-incidence of the diseases with the detection of Fusobacterium necrophorum subsp. necrophorum (Fnn) and its encoded leukotoxin (lktA) gene. Sequence analyses showed that the outer membrane protein of Fnn in the GenBank database shared significant homology (99%) with the Fnn encoded haemagglutinin-related-protein gene fragment identified in this study. In addition, this report suggests the existence of a variant of Fnn with no detectable lktA gene and thus warrants further studies. In contrast to reports associating Porphyromonas gingivalis and F. nucleatum with PD, this study revealed that PD in macropods are associated with Porphyromonas gulae and Fnn and raises the question: is there a possible host pathogen co-evolution in the pathogenesis of PD in animals and humans? These findings contribute to the understanding of the aetiology of periodontal disease in macropods as well as opening up a new direction of research into the microbial interactions involved in the pathogenesis of PD in macropods.
Keywords: Periodontopathogens
Periodontal disease
Molecular survey
Fusobacterium necrophorum
Rights: © 2013 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.vetmic.2013.01.012
Appears in Collections:Animal and Veterinary Sciences publications
Aurora harvest 4

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