Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/78422
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Type: Journal article
Title: Exercising the worry away: How inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours
Author: Moylan, S.
Eyre, H.
Maes, M.
Baune, B.
Jacka, F.
Berk, M.
Citation: Neuroscience and Biobehavioral Reviews, 2013; 37(4):573-584
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2013
ISSN: 0149-7634
1873-7528
Statement of
Responsibility: 
S. Moylan, H.A. Eyre, M. Maes, B.T. Baune, F.N. Jacka, M. Berk
Abstract: Regular physical activity exerts positive effects on anxiety disorder symptoms, although the biological mechanisms underpinning this effect are incompletely understood. Numerous lines of evidence support inflammation and oxidative and nitrogen stress (O&NS) as important in the pathogenesis of mood and anxiety disorders, and physical activity is known to influence these same pathways. This paper reviews the inter-relationships between anxiety disorders, physical activity and inflammation and O&NS, to explore whether modulation of inflammation and O&NS may in part underpin the positive effect of physical activity on anxiety disorders. Numerous studies support the notion that physical activity operates as an anti-inflammatory and anti-O&NS agent which potentially exerts positive effects on neuroplasticity, the expression of neurotrophins and normal neuronal functions. These effects may therefore influence the expression and evolution of anxiety disorders. Further exploration of this area may elicit a deeper understanding of the pathogenesis of anxiety disorders, and inform the development of integrated programmes including PA specifically suited to the treatment and prevention of anxiety disorders and symptoms.
Keywords: Physical activity
Exercise
Anxiety disorders
Inflammation
Oxidative stress
Neuroplasticity
Neurotrophins
Apoptosis
Treatment
Prevent
Rights: © 2013 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.neubiorev.2013.02.003
Appears in Collections:Aurora harvest
Psychiatry publications

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