Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7873
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Type: Journal article
Title: Synthesis of hydroperoxide and perketal derivatives of polyunsaturated fatty acids as potential antimalarial agents
Author: Pitt, M.
Easton, C.
Robertson, T.
Kumaratilake, L.
Ferrante, A.
Poulos, A.
Rathjen, D.
Citation: Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 1998; 39(24):4401-4404
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Issue Date: 1998
ISSN: 0040-4039
Abstract: Hydroperoxide derivatives of ╬▓-oxa-substituted polyunsaturated fatty acids were prepared by 15-1ipoxygenase catalysed oxidation and perketal derivatives of fatty acid hydroperoxides were synthesized. The perketals are more stable than their parent fatty acid hydroperoxides, but less active as antimalarial agents in the in vitro growth inhibition of Plasmodium falciparum.
DOI: 10.1016/S0040-4039(98)00747-3
Appears in Collections:Aurora harvest 4
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