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Type: Journal article
Title: Ultrasound enhanced release of therapeutics from drug-releasing implants based on titania nanotube arrays
Author: Aw, M.
Losic, D.
Citation: International Journal of Pharmaceutics, 2013; 443(1):154-162
Publisher: Elsevier Science BV
Issue Date: 2013
ISSN: 0378-5173
Statement of
Moom Sinn Aw, Dusan Losic
Abstract: A non-invasive and external stimulus-driven local drug delivery system (DDS) based on titania nanotube (TNT) arrays loaded with drug encapsulated polymeric micelles as drug carriers and ultrasound generator is described. Ultrasound waves (USW) generated by a pulsating sonication probe (Sonotrode) in phosphate buffered saline (PBS) at pH 7.2 as the medium for transmitting pressure waves, were used to release drug-loaded nano-carriers from the TNT arrays. It was demonstrated that a very rapid release in pulsatile mode can be achieved, controlled by several parameters on the ultrasonic generator. This includes pulse length, time, amplitude and power intensity. By optimization of these parameters, an immediate drug-micelles release of 100% that spans a desirable time of 5–50 min was achieved. It was shown that stimulated release can be generated and reproduced at any time throughout the TNT-Ti implant life, suggesting considerable potential of this approach as a feasible and tunable ultrasound-mediated drug delivery system in situ via drug-releasing implants. It is expected that this concept can be translated from an in vitro to in vivo regime for therapeutic applications using drug-releasing implants in orthopedic and coronary stents.
Keywords: Local drug delivery
Titania nanotubes
Stimulated drug-micelles release
Drug carrier
Polymeric micelles
Rights: Crown Copyright © 2013 Published by Elsevier B.V. All rights reserved.
DOI: 10.1016/j.ijpharm.2013.01.004
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Appears in Collections:Aurora harvest 4
Chemical Engineering publications

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