Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79022
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Type: Journal article
Title: Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata
Author: Boattini, A.
Adler, C.
Cooper, A.
Dersarkissian, C.
Haak, W.
Citation: PLoS One, 2013; 8(5):1-12
Publisher: Public Library of Science
Issue Date: 2013
ISSN: 1932-6203
1932-6203
Contributor: Adler, Christina Jane
Cooper, Alan
Dersarkissian, Clio Simone Irmgard
Haak, Wolfgang
Statement of
Responsibility: 
Alessio Boattini, Begoña Martinez-Cruz, Stefania Sarno, Christine Harmant, Antonella Useli, Paula Sanz, Daniele Yang-Yao, Jeremy Manry, Graziella Ciani, Donata Luiselli, Lluis Quintana- Murci, David Comas, Davide Pettener, the Genographic Consortium
Abstract: Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in ~900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West–South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in Europe.
Keywords: Genographic Consortium; Chromosomes, Human, Y; Humans; DNA, Mitochondrial; Cluster Analysis; Genetics, Population; Phylogeny; Haplotypes; Geography; Principal Component Analysis; Time Factors; Italy; Female; Male; Genetic Variation
Description: University of Adelaide Genographic Consortium contributers: Christina J. Adler, Alan Cooper, Clio S. I. Der Sarkissian, Wolfgang Haak.
Rights: © 2013 Boattini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020128902
DOI: 10.1371/journal.pone.0065441
Appears in Collections:Environment Institute publications
Earth and Environmental Sciences publications

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