Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79062
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Type: Journal article
Title: Effect of PDGF-BB and beta-tricalcium phosphate (β-TCP) on bone formation around dental implants: A pilot study in sheep
Other Titles: Effect of PDGF-BB and beta-tricalcium phosphate (beta-TCP) on bone formation around dental implants: A pilot study in sheep
Author: Choo, T.
Marino, V.
Bartold, P.
Citation: Clinical Oral Implants Research, 2013; 24(2):158-166
Publisher: Munksgaard Int Publ Ltd
Issue Date: 2013
ISSN: 0905-7161
1600-0501
Statement of
Responsibility: 
Tina Choo, Victor Marino, P. Mark Bartold
Abstract: OBJECTIVES The aim of this investigation was to examine the effect of a combination of purified recombinant human platelet-derived growth factor (rhPDGF-BB) mixed with a synthetic beta-tricalcium phosphate (β-TCP) on bone healing around dental implants with critical size CIRCUMFERENTIAL DEFECTS. MATERIAL AND METHODS Three critical size circumferential defects were prepared in the ilium of six sheep. Three dental implants were placed into the centre of each defect and the 3.25 mm circumferential gap was filled with (a) blood clot alone; (b) β-TCP; (c) rhPDGF-BB (0.3 mg/ml) with β-TCP. All the defects in each group were covered with a Bio-Gide® resorbable barrier membrane. The sheep were sacrificed at 2 and 4 weeks and histological and histomorphometric analyses were performed to determine the percentage of new mineralized bone formation and residual β-TCP graft particles in the defects. RESULTS Defects filled with rhPDGF-BB/β-TCP showed the highest rate of bone formation after 2 and 4 weeks with limited degradation of the β-TCP particles over 4 weeks. Defects filled with β-TCP showed the least bone fill after 2 and 4 weeks, and faster degradation of the β-TCP particles over 4 weeks compared with defects filled with rhPDGF-BB/β-TCP. Percentage of new mineralized bone was comparable in defects to blood clot alone and β-TCP after 4 weeks of healing, but there was a collapse in the defect area in defects with blood clot alone. In comparison, the space was maintained when β-TCP was used in defects at 4 weeks. CONCLUSIONS Defects which had β-TCP alone showed an inhibition in bone healing at 2 and 4 weeks; however, the combination of rhPDGF-BB with β-TCP enhanced bone regeneration in these peri-implant bone defects at the same time intervals.
Keywords: bone formation; dental implants; growth factors
Rights: © 2011 John Wiley & Sons A/S
RMID: 0020124751
DOI: 10.1111/j.1600-0501.2011.02345.x
Appears in Collections:Dentistry publications

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