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Type: Journal article
Title: Dietary lipids and functional gastrointestinal disorders
Author: Feinle-Bisset, C.
Azpiroz, F.
Citation: American Journal of Gastroenterology, 2013; 108(5):737-747
Publisher: Blackwell Publishing Ltd
Issue Date: 2013
ISSN: 0002-9270
Statement of
Christine Feinle-Bisset and Fernando Azpiroz
Abstract: There is convincing evidence that patients with functional gastrointestinal disorders (FGIDs) exhibit dysfunctions of the gut involving hypersensitivity and abnormal reflexes, so that physiological, normally unperceived, stimuli induce symptoms. The type of symptoms depends on the specific sensory-reflex pathways and region(s) affected. Fat modulates the responses of the gut to various stimuli, and some of these modulatory mechanisms are abnormal in patients with FGIDs. Indeed, laboratory-based studies have shown that the symptoms experienced by these patients can be induced, or exacerbated, by administration of lipids in amounts that are well tolerated by healthy controls, and, thus, demonstrate a hypersensitivity to lipid. Very few studies have evaluated dietary patterns and eating behavior in these patients, with often-conflicting outcomes, and no studies have been performed to evaluate the role of targeted dietary interventions for the relief of symptoms. Given the evidence from laboratory studies, as well as patient experience, such studies, in large cohorts of patients, are needed with the view to develop personalized, cost-effective treatment approaches.
Keywords: Humans
Gastrointestinal Diseases
Gastroesophageal Reflux
Irritable Bowel Syndrome
Gastrointestinal Hormones
Dietary Fats
Feeding Behavior
Evidence-Based Medicine
Gastrointestinal Motility
Intestinal Absorption
Rights: © 2013 by the American College of Gastroenterology
DOI: 10.1038/ajg.2013.76
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